Gut microbiome disruptions in depression: shifting the focus to metabolic signatures in blood

It is estimated that each year, 6% of the adult population worldwide experience the debilitating mental health disorder that is major depression (MDD) (Otte et al. 2016). Considerable uncertainty remains about the neurobiological basis for depression and new leads are urgently required to support diagnosis and improve treatment options. What if new therapeutic targets lie below rather than above the neck?

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